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The effect of the simple
2021-08-10
The effect of the simple dopaminergic tonic/phasic model on cognitive processing has been investigated by a few studies (Nolan et al., 2004; Rosa et al., 2010). Rosa et al. (2010), using a Stroop task that requires different levels of cognitive flexibility and stability, observed an association betw
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To provide a brief critical
2021-08-10
To provide a brief critical evaluation of this technology and an outlook, we note that performance of SMEPT is critically dependent on each of the components making up this platform, namely the substrate, the enzyme, and the prodrug. With regards to the latter, SMEPT is built on the experience and s
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During the course of enzymatic digestion protein is
2021-08-10
During the course of enzymatic digestion, protein is digested into large peptides and these large peptides are then further digested into small fragments. αs1-Casein f15–39, which contains 25 amino AG 1879 residues was the longest iTRAQ-labelled peptide identified in the samples digested with GE at
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br Results br Discussion Previous studies
2021-08-09
Results Discussion Previous studies have mapped ABCF1 as a risk factor gene for rheumatoid arthritis and autoimmune pancreatitis (Ota et al., 2007, Richard et al., 1998). Additionally, recent genome-wide association studies have also associated ABCF1 with the risk of gout (Dong et al., 2017) a
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Several functions of FAT have been suggested It has
2021-08-09
Several functions of FAT10 have been suggested. It has been shown that FAT10 binds noncovalently to the mitotic spindle checkpoint protein MAD2 and that this binding might cause chromosome instability in the cancer cancer overexpressing FAT10 (Liu et al., 1999, Ren et al., 2006). In other studies,
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br Results and Discussion br Conclusions
2021-08-09
Results and Discussion Conclusions Understanding the connections between function and fitness is a primary goal of many biological disciplines including systems biology and molecular evolution. While sound approaches have been developed to understand the connections between function and fitnes
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We found that the postnatal absence of norepinephrine
2021-08-09
We found that the postnatal absence of norepinephrine yields differing effects depending on noradrenergic receptor type and Isoxsuprine hydrochloride region. The density of α1-AR, indicated by [3H]prazosin binding was similar between Dbh+/− and Dbh−/− mice except for a significant increase in hippoc
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DNA PK Jackson is activated
2021-08-09
DNA-PK (Jackson, 1997) is activated by DNA double-stranded breaks (DSBs). It is a trimeric complex composed of the catalytic subunit, DNA-PKcs, and the Ku70/80 heterodimer. DNA-PK mediates non-homologous end joining (NHEJ), which joins programmed DSBs created during V(D)J recombination and class swi
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Letrozole sale Many studies have found that there is
2021-08-09
Many studies have found that there is an aberrant DNA methylation in the imprinting control region of development-related genes in the spermatozoa of oligozoospermic men (Kobayashi et al, 2007, Marques et al, 2004, Marques et al, 2008), which most likely results from expressional changes in the DNMT
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DNA hypomethylation has been found in liver tumor and other
2021-08-09
DNA hypomethylation has been found in liver tumor and other tumors of humans, such as laryngeal cancer, additional info tumors, tongue squamous cell carcinoma and uterine leiomyomas [[20], [21], [22], [23], [24]]. Then, we mainly sought to confirm whether TCA could induce DNA hypomethylation in vitr
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br Conflict statement br Introduction Prostate cancer PCa
2021-08-09
Conflict statement Introduction Prostate cancer (PCa) is the second most frequently diagnosed cancer and the second leading cause of cancer death in men after lung cancer [1], [2]. The incidence and mortality rate of prostate cancer are significantly higher in developed countries especially th
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myc pathway br Materials and methods br Acknowledgments
2021-08-09
Materials and methods Acknowledgments Introduction Proton pumps convert the energy of high-energy compounds into the myc pathway of protons across biomembranes. They play two physiological roles: pH regulation and the formation of proton-motive forces in their membranes. The simplest of the
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br Results br Discussion Adult hand foot and
2021-08-09
Results Discussion Adult hand, foot and mouth disease gets no particular research interest because it has been seen as a sporadic mild viral infection that spontaneously resolved in a few days. However, evidence showed that adults may act as latent enterovirus reservoirs. A serum epidemiologic
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dpp-4 inhibitors br Acknowledgements br Introduction Anxiety
2021-08-09
Acknowledgements Introduction Anxiety and depression are major components of maintaining the cycle of addiction, and are responsible for the negative reinforcement of drug seeking behaviors (Sarnyai et al., 1995, Koob and Le Moal, 2008). Both rats and humans exhibit increased anxiety states du
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We further correlated OPRK and OPRM methylation levels with
2021-08-09
We further correlated OPRK1 and OPRM1 methylation levels with individual characteristics in Xinjiang Han and Uygur controls. Partial correlation analyses showed that OPRK1 methylation was positively correlated with age in Uygur male controls (r=0.72, p=0.001, adjusted by body mass index (BMI), gluco
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