• Epigenetic modifications DNA methylation in particular

  2018-11-06

  

  Epigenetic modifications, DNA methylation in particular, regulate key developmental processes including germ cell imprinting and stem cell maintenance/differentiation and play a crucial role in the early periods of embryogenesis (Bartolomei, 2003; Kiefer, 2007; Kondo, 2006; Surani et al., 2007). DNA

• To develop an effective cell based therapy against

  2018-11-06

  

  To develop an effective cell-based therapy against neurodegenerative disorders of the CNS, efficient recruitment of the cells into the CNS is essential. Previous findings suggest that particular bone marrow derived cells are able to cross the blood–brain barrier (Lebson et al., 2010; Simard and Rive

• br Introduction Thyroid hormone TH is a critical regulator o

  2018-11-06

  

  Introduction Thyroid hormone (TH) is a critical regulator of many physiological and developmental processes, following its activation from the stable prohormone (l-thyroxine, T4) to the short-lived active hormone, triiodothyronine (3,5,3′-triiodo-l-thyronine, T3) (Fig. 1). T3 induces amphibian me

• In the present study we tested five different pharmacologica

  2018-11-06

  

  In the present study, we tested five different pharmacological agents that are commonly used as selective inhibitors of Nodal/Activin signaling, namely SB431542, LY364947, A-83-01, SB505124, and SB525334 (Inman et al., 2002; Callahan et al., 2002; Laping et al., 2002; DaCosta Byfield et al., 2004; L

• In accordance with our previous observations Salazar et

  2018-11-06

  

  In accordance with our previous observations (Salazar et al., 2010), hCSN-SCns transplanted at the early-chronic stage of SCI exhibited migration away from the injury epicenter, as well as a preferential rostral localization in migration and proliferation. These data may suggest that extrinsic facto

• In addition to PES pre treatment increasing HPC adhesion wit

  2018-11-06

  

  In addition to PES pre-treatment increasing HPC7 adhesion within the colon, it also concomitantly reduced pulmonary presence, thereby reducing non-specific retention in healthy tissues. Pulmonary entrapment is a major obstacle for systemic HSPC delivery for regenerative purposes both experimentally

• Using murine ESCs Correa Cerro et

  2018-11-06

  

  Using murine ESCs, Correa-Cerro et al. (2011) screened the effect of single overexpressed TFs from a panel of 137 transcription factors and selected for those which had the ability to induce a transcriptome shift towards specific lineages at 48h post induction. They followed that report by testing s

• br Materials and methods br Acknowledgments This study was s

  2018-11-06

  

  Materials and methods Acknowledgments This study was supported by postdoctoral research station of Central South University and funded by China Postdoctoral Science Foundation (2014M560650 to S.Z.), the National Natural Science Foundation of China (grant number 31401248 to S.Z.). We thank the

• It is puzzling to observe in this study that the

  2018-11-05

  

  It is puzzling to observe in this study that the stabilizing β-catenin mutation, which acts dominantly in many other tissues, affected the GFRα1+ cell pool only when introduced homozygously, and that heterozygous deletion of β-catenin caused affected spermatogenesis. These findings imply that Wnt/β-

• Fig b shows that the

  2018-11-05

  

  Fig. 1b shows that the population of the upper sublevel of the 4I11/2 multiplet with the s1p receptor of 2110 cm−1 does not depend on the rate of relaxation transitions relaxation to the main 4I9/2 level. The calculations proved that in order to adequately model the changes of the emission spectru

• The underlying idea of the

  2018-11-05

  

  The underlying idea of the tomographic method is in reconstructing f(x, y), i.e. the density distribution function (or distribution of any other quantity) in the plane [3]. The initial data are sets of Radon images Rφ(s) that are projections of the functions f(x, y) on the set of the corresponding

• To our knowledge this is the first study to

  2018-11-05

  

  To our knowledge, this is the first study to empirically test the claim that flexicurity policies have the capacity to attenuate the adverse health consequences of temporary employment across a large sample of advanced capitalist countries. Prior studies have challenged the notion that flexicurity c

• Among patients diagnosed with breast cancer a poor

  2018-11-05

  

  Among patients diagnosed with breast cancer, a poor prognosis is more frequent among women with a lower SES (Byers et al., 2008; Halmin et al., 2008; Kravdal, 2000; Louwman, van de Poll-Franse, Fracheboud, Roukema, & Coebergh, 2007), and this substance p relationship has been shown to relate to dif

• Food insecurity is associated with a range of negative

  2018-11-05

  

  Food insecurity is associated with a range of negative health outcomes, including poor physical health of infants, low educational achievement among children, mental health issues among adolescents and adults, and nutrient deficiencies (Fox and Cole, 2004). The diets of food insecure individuals and

• br Discussion Our second finding is

  2018-11-05

  

  Discussion Our second finding is that more than half (11 out of 18) of the environmental variable/AC associations examined were statistically different between rural and urban tracts. Four of these coefficients had the same direction but varied in effect size, but seven of these coefficients had

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