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br Methods br Results br Discussion This is
2018-10-30
Methods Results Discussion This is the first study reporting normal values of blood LAL activity in healthy adult subjects; we found a median value of LAL activity of 1.15nmol/spot/h, with no age and sex differences. We also investigated LAL activity in a cohort of adult patients with NAFLD
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Sub lethal levels of MP MUS induce increased levels of
2018-10-30
Sub-lethal levels of MP-MUS induce increased levels of mitochondria and mitochondrial MAOB in glioma cells in vitro and in vivo. Cells derived from MP-MUS-treated glioma xenografts harbored dysfunctional mitochondria many generations after treatment. The mitochondria in these cells had increased MAO
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Assuming that the claimed effect of meclizine in male mice
2018-10-30
Assuming that the claimed effect of meclizine in male mice on renal ischemia–reperfusion injury is real, there are still a couple of uncertainties that hinder translation to humans. The observation might be species and/or gender specific (). Replication in larger mammals including both sexes is ther
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For a better three dimensional impression Fig provides
2018-10-30
For a better three-dimensional impression Fig. 4 provides exemplary views of volume renderings of the acquired datasets. Bones were segmented from the attenuation signal, whereas lung tissue was extracted from the DFCTs and represented by a semi-transparent hot color map to enhance inter- and intra-
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br Methods br Results Plasma NFL concentrations were
2018-10-30
Methods Results Plasma NFL concentrations were within the linear range of the assay in all samples, Fig. 1a. It was thus possible to quantify plasma NFL in all subjects analyzed, despite more than 50-fold lower concentrations than in CSF. This included the HIV-negative controls and other subje
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Given the phase trial results we sought
2018-10-30
Given the phase 1 trial results, we sought to address a complementary question whether VIS410 could be successfully deployed in the event of an epidemic outbreak to improve public health outcomes. We predicted that given VIS410\'s half-life, its distribution to the primary site of influenza A infect
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Another critical alteration in Pgam deficient BAT under
2018-10-30
Another critical alteration in Pgam5-deficient BAT under fasting and cold stress is the enhancement of FGF21 (Fig. 4a and d). Because the pre-treatment of ISRIB almost completely blocked the enhancement of Fgf21 YO-01027 in Pgam5-deficient BAT (Fig. 4e), phospho-eif2α-ATF4 pathway may be involved i
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Calcium Ionophore I Today recent technological advances have
2018-10-30
Today, recent technological advances have dramatically improved the prospect of applying broadly the concept of precision medicine. Large-scale databases, omics technologies, cellular assays, epigenetics, informatics as well as imaging technologies converge towards optimum disease prevention, diagno
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br Materials and Methods br Results br
2018-10-30
Materials and Methods Results Discussion While circadian clocks throughout the body clearly play a role in regulating metabolic pathways and their homeostatic function, increasing evidence for diet-induced alterations in clock gene oscillations and behavioral rhythms suggests that nutrient
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3X FLAG In the nearly years since the clevidipine
2018-10-30
In the nearly 18years since the clevidipine investigational new drug application was filed, our understanding of the structure, tissue distribution and molecular biology of the l-type calcium channels (LTCC) has evolved dramatically (Zuccotti et al., 2011; Abernethy and Soldatov, 2002). The CaV-α-1
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SAR302503 br Experimental design materials and methods br Da
2018-10-29
Experimental design, materials and methods Data The data include table and figures, which help analyze the phosphorylated peptides and DSP. The peptic peptides detected by LC FTICR MS after 5min SAR302503 of natural ovalbumin as control are listed in Supplementary Table 1. Compared with the c
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br Model fitting methods Model fitting
2018-10-29
Model fitting methods Model fitting methods are based on the different models fittings at a particular temperature obtained from DTG curve and also determine the values of activation energy and pre-exponential factor. Many non-isothermal model fitting methods are available but Kissinger model is
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br Amygdala striatal interactions in maturity The unidirecti
2018-10-29
Amygdala-striatal interactions in maturity The unidirectional glutamatergic projections from the BLA to the ventral striatum (Everitt et al., 1991; Groenewegen et al., 1999; Robbins et al., 1989) facilitate the ventral striatum’s role as an interfacing region able to translate evaluative signals
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Como sujetos no deseados de la ciencia y sujetos impropios
2018-10-29
Como sujetos no deseados de la ciencia y sujetos impropios/inapro- piados del feminismo, las activistas intersexuales politizadas tenemos intereses profundos en aliarnos con y participar en la clase de trabajo cultural postestructuralista que evidencia las suposiciones fundacionales sobre la persona
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br Domain specific survey of IoT
2018-10-29
Domain specific survey of IoT cloud platforms This section presents 26 IoT cloud platforms according to their appropriateness into the specific application domains. It is obvious that there are many more platforms present in the market, but due to tech-specific and time limits 26 of these are cho
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