• We continued to investigate the

  2019-07-13

  

  We continued to investigate the contribution of the EP1 PD 169316 to nociceptive sensitization by utilizing its natural ligand PGE and tested the effect of local subcutaneous injection of PGE (5nmol in 5μl) into one hindpaw on mechanical and heat pain thresholds. Wild-type mice displayed maximum se

• In addition to vasoconstrictor actions acute effects ET exer

  2019-07-13

  

  In addition to vasoconstrictor actions (acute effects), ET-1 exerts potent mitogenic actions on vascular smooth muscle cells and cardiac myocytes (chronic effects), hence causing vascular and cardiac hypertrophy [19,24,25]. These effects are mediated via stimulation of either ETA or ETB receptors, a

• Several studies on the collagen

  2019-07-13

  

  Several studies on the collagen receptor DDR1 have revealed a defined collagen signaling pathway that causes cell scattering and cadherin switching. As mentioned earlier, DDR Valrocemide molecular on collagens are distinct from integrin binding sites; therefore, the same collagen protein can bind t

• The generation of ROS in addition to eliciting oxidative

  2019-07-13

  

  The generation of ROS, in addition to eliciting oxidative stress, is an important proapoptotic signal (Ott et al., 2007). Apoptosis is clearly associated with the production of ROS, since ROS generation occurs in the mitochondrial respiratory chain and disturbs mitochondrial homeostasis, which plays

• In addition to playing important roles in the immune system

  2019-07-13

  

  In addition to playing important roles in the immune system, EBI2 is also expressed in the CGP 54626 hydrochloride weight of the central nervous system (CNS), namely astrocytes, and this receptor regulates astrocyte signalling, as well as astrocyte cell migration (Rutkowska et al., 2015, Rutkowska e

• In plants SUMOylation has been shown to

  2019-07-13

  

  In plants, SUMOylation has been shown to modulate plant hormone signaling (Lois et al., 2003, Miura et al., 2009, Conti et al., 2014), root stem cell maintenance (Xu et al., 2013), and responses to abiotic and biotic stress (Lois, 2010). Many of the plant biological processes regulated by SUMOylatio

• Due to its several industrial

  2019-07-13

  

  Due to its several industrial applications, the recombinant production of collagen and all its derivatives as gelatins has been pursued for many years in different biological systems as mammalian AZD1080 (Toman et al., 1999), tobacco plants (Ruggiero et al., 2000), silkworms (Tomita et al., 2003) a

• Although CK phosphorylated Msn as well as Msn

  2019-07-13

  

  Although CK2 phosphorylated Msn4 as well as Msn2 (Fig. 1A), the two CK2-dependent phosphorylation sites in Msn2 are not conserved in Msn4. Thus, Msn2 and Msn4 might be differently regulated by CK2-dependent phosphorylation. Msn2 and Msn4, which have 41% identity and similarity in size and amino CCK

• We experienced difficulties in observing maturation of

  2019-07-13

  

  We experienced difficulties in observing maturation of hESC retinas in rd1 mice even with immunosuppression, but with NOG-rd1-2J mice the transplanted hESC retinas consistently developed mature ONL with rod and cone opsins. Furthermore, graft photoreceptors show signs of developing IS/OS structures

• Enhanced oxidative stress has been suggested as

  2019-07-13

  

  Enhanced oxidative stress has been suggested as the critical mechanisms of IS-produced muscle damage [41,42]. NAC as a direct reactive oxygen species ROS scavenger is frequently discussed in the clinical trials of radiocontrast-induced AKI prevention [43]. Despite some supportive epidemiological dat

• br O GlcNAc transferase OGT belongs to the metal independent

  2019-07-13

  

  O-GlcNAc transferase OGT belongs to the metal-independent GT-B superfamily of glycosyltransferases, which has been well-reviewed previously [14,15]. OGT is an essential gene encoded on the X-chromosome, and it has two main regions: a long N-terminal tetratricopeptide repeat (TPR) region and a C-t

• In addition to providing substantial insight into substrate

  2019-07-13

  

  In addition to providing substantial insight into substrate recognition, structural studies have revealed important details about mechanisms of glycosylation and HCF-1 cleavage [28,30,33]. Activation of the nucleotide-sugar is accomplished through interactions of the β-phosphate with the N-terminus

• Another interesting finding regarding substrate selectivity

  2019-07-13

  

  Another interesting finding regarding substrate selectivity of iPLA2-VIA in whole cellular systems stems from the observation that some of the major species hydrolyzed by the enzyme contain a 16:1 fatty TC-E 5003 at the sn-2 position [57,119], raising the possibility that iPLA2-VIA may constitute a

• In summary our findings show that LPS can activate

  2019-07-12

  

  In summary, our findings show that LPS can activate CysLT2R on microglial thymidylate synthase inhibitors to induce microglial inflammation and microglia-dependent neuronal death. Furthermore, pharmacological inhibition or knocking down of CysLT2R expression protects neurons against neurotoxicity v

• The nuclear receptor related protein Nurr NR A is

  2019-07-12

  

  The nuclear receptor related-1 protein, Nurr1 (NR4A2), is a transcription factor that regulates the AM 281 of genes critical for the development, maintenance, and survival of dopaminergic neurons (Alavian et al., 2014, Decressac et al., 2013, Dong et al., 2016, Jankovic et al., 2005, Johnson et al.

15867 records 991/1058 page Previous Next First page 上5页 991992993994995 下5页 Last page