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br Materials and methods br
2023-04-18
Materials and methods Results and discussion Conclusion Introduction Free radicals produced by normal oxidative metabolism in the human body can cause chain oxidation of food, accelerate food deterioration and cause serious problems of food safety (Choe & Min, 2006). Excess free radicals
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Overall we found maternal antibiotics to
2023-04-17
Overall, we found maternal 2-Amino-ATP to be associated with improved outcomes. In these multiple logistic regression models, high postnatal empiric infant antibiotic exposure was not significantly associated with risk for NEC or LOS. However, consistent with previous studies,5, 6 receipt of high e
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br Materials and method br
2023-04-17
Materials and method Results and discussion Conclusion The adsorption behaviors of 5 antibiotics on 5 types of microplastic particles were investigated using batch type experiments. Our results showed that adsorption capacities varied among antibiotics, plastic types, and environmental cond
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Perhaps the first evidence of AMPKs therapeutic ability
2023-04-17
Perhaps the first evidence of AMPKs therapeutic ability in DM1 came from Thomas Cooper’s laboratory where they demonstrated that insulin-independent glucose uptake was unaffected in human DM1 muscle AVE-1625 treated with MET, an AMPK activator and first-line therapy for type 2 diabetes mellitus [76]
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br AMPK as a druggable
2023-04-17
AMPK as a druggable target AMPK signaling has attracted considerable attention within the past decades, owing to the capacity of pharmacological compounds (e.g., 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside [AICAR] and metformin) or natural compounds (e.g., resveratrol) to activate AMPK in
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br Stress glucocorticoids as risk factor for Alzheimer
2023-04-17
Stress/glucocorticoids as risk factor for Alzheimer’s Disease: preclinical studies A role for glucocorticoids in shaping the risk for AD is supported by animal studies using rats or mice injected with Aβ oligomers, tau protein or excitotoxins, or transgenic (Tg) mice carrying mutations associated
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A key building block in MT
2023-04-17
A key building block in MT-SGL is the computation of the proximal operator in (12) when is the multi-task sparse group lasso regularizer given byFor MT-SGL, the iterates x ≡ Θ are matrices, and the proximal operator is computed at z ≡ Z = Θ + α(Θ − Θ). For the loss function L(·) corresponding to Ga
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wnt inhibitor Interestingly as observed with Treg cells
2023-04-17
Interestingly, as observed with Treg cells, adenosine can regulate the function of Breg cells, a subset of immunosuppressive cells that support immunological tolerance [115]. In particular, Bregs were able to regulate both their own function and T cell activity via an adenosine signaling originating
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br LO and the secretase complex Supporting
2023-04-17
5LO and the γ-secretase complex Supporting this concept, during a recent trial testing the γ-secretase inhibitor semagacestat (LY 450139), AD patients actually experienced a functional decline compared to patients who took a placebo in addition to several other significant adverse effects (Doody
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br Conclusion The HT receptor
2023-04-17
Conclusion The 5-HT receptor family is complex, and one may ask as does Bryan Roth et al. [205] whether this is useless 2400 7 (i.e. too much redundancy) or an embarrassment of the riches (i.e. many potential targets to choose from to affect normal or pathological function); molecular biology ha
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NSAIDs induce gastrointestinal toxicity and evoke asthma by
2023-04-17
NSAIDs induce gastrointestinal toxicity and evoke glucose transporter by decreasing the production of gastroprotective prostanoids and by redirecting the COX substrate AA into LT biosynthesis, thereby causing vasoconstriction in gastric mucosa and airways (Celotti and Laufer, 2001; Koeberle and Wer
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TG101348 br Autophagy in cancer br Phytochemicals as a valua
2023-04-17
Autophagy in cancer Phytochemicals as a valuable source of autophagy modulation agents Epidemiological studies demonstrated that there is a strong association between diet and human cancer mortality so that daily consumption of phytochemicals declines the incidence of different types of cancer
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Treatment of all of the
2023-04-17
Treatment of all of the GYN cancer N,N-Dimethylsphingosine mg in this study with ATRi not only reduced phosphorylation of Chk1 at Ser345 following genotoxic stress, but also phosphorylation of ATM. Loss of phospho-ATM following ATRi treatment is not likely due to non-specific targeting of ATM by ET
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br Materials and methods br Results
2023-04-17
Materials and methods Results Discussion Despite the relative complexity of immunotherapy, such treatment may have an important role, in conjunction with other therapies in the treatment of cancer refractory to conventional treatments alone. Clinical studies have recently shown that adding
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In a study highlighted the usefulness of arginase as
2023-04-17
In 2010, a study highlighted the usefulness of arginase-1 as a sensitive and specific marker of hepatocytic differentiation for diagnostic pathology [9]. Subsequent studies have validated the high sensitivity and specificity of arginase-1, in particular its added value in evaluating poorly different
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