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Hsp also called FK binding protein
2025-02-08
Hsp56 (also called FK506-binding protein 52, FKBP52) is one of the steroid receptor-associated immunophilins with tetratricopeptide repeat domains, which serve as binding sites for Hsp90 (Peattie et al., 1992). Hsp56 is elevated in breast cancer compared with normal breast tissue (Ward et al., 1999)
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faah inhibitors br Concluding remarks br Conflict of
2025-02-08
Concluding remarks Conflict of interest Acknowledgment This work was supported by the H.E.B. Endowed Chair in Marine Science (to P.T.) and University of Texas Marine Science Institute endowment-supported scholarships (to A.C). Introduction Disorders of sex development (DSD) are defined
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As noted above yeasts particularly S cerevisiae Frey
2025-02-08
As noted above, yeasts, particularly S. cerevisiae (Frey and Röhm 1978; Trumbly and Bradley 1983), produce APs, but these are intracellular enzymes located in the vacuolar compartment, with the exception of aminopeptidase II. About 40% of aminopeptidase II activity is detected as external enzyme, li
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orphan receptor Recently two distinct small molecule
2025-02-08
Recently, two distinct small-molecule inhibitors of PHGDH were identified using high-throughput screens, both of which inhibit de novo serine biosynthesis and show selective toxicity to cancer orphan receptor with high SSP flux [50,51]. The inhibitor NCT-503, which has an IC50 of 2.5μM, reduces the
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br Introduction Alzheimer s disease
2025-02-08
Introduction Alzheimer's disease (AD) is a neurodegenerative disorder and the leading cause of dementia. It is characterized by progressive and irreversible damage to different Cytotoxicity assay areas, resulting in cognitive impairment and behavioral changes (O'Neill, 2013, De Strooper and Karr
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br Experimental br Acknowledgment br Introduction The
2025-02-08
Experimental Acknowledgment Introduction The NADPH-dependent reduction of d-glucose catalyzed by aldose reductase (E.C.1.1.1.21) (AR) is considered as one of the phenomena leading to the onset of long term diabetic complications [as review see: [1], [2]. In fact, the reduction of the sugar,
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DMG-PEG2000-NHS linker Ginsenosides are the major bioactive
2025-02-08
Ginsenosides are the major bioactive constituents of the Panax ginseng root, which contain many types of ginsenosides including Rb1, Rg1, Rc, and Rg3. The ginsenoside Rb1 appears to be the most abundant of the bioactive ginsenosides [15]. Rb1 exhibits antiinflammatory, anticarcinogenic, and antioxid
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br Introduction The chronic inflammation
2025-02-08
Introduction The chronic inflammation is one of the leading events involved in the aetiology of many chronic-degenerative diseases including diabetes, atherosclerosis, arthritis and cancer (Coussens and Werb, 2002). Monocytes/macrophages lineage plays an important role during inflammation through
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c di gmp Similarly Dilma et al tried
2025-02-08
Similarly Dilmaç et al. [16] tried to assess the diagnostic value of adenosine deaminase activity in sputum of patients with pulmonary tuberculosis, their aim was to determine and compare sputum ADA activity in pulmonary tuberculosis, lung cancer and chronic obstructive pulmonary disease (COPD) pati
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It is well accepted that
2025-02-08
It is well accepted that PKA is a key enzyme activated at the beginning of the capacitation process [69]. As mentioned above phosphorylation/inactivation of cofilin in sperm is a PKA dependent process [58]. We could not see any change in cofilin phosphorylation level by adding the PKA activator 8Br-
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Plant material and growth conditions Arabidopsis thaliana
2025-02-08
Plant material and growth conditions. Arabidopsis thaliana ecotype Columbia was grown on a mixture of soil, vermiculite, and perlite (4:2:1) with a 16h light/8h dark anatoxin a synthesis in a temperature-controlled growth room (22°C), unless indicated otherwise. Molecular cloning and plant transfor
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ACK can be localized to clathrin
2025-02-08
ACK1 can be localized to clathrin-coated vesicles [1]. The association of SNX9 with synaptojanin-1 would suggest the two cooperate during endocytosis at the synapse by coupling the sorting nexin to changes in phospholipid composition. ACK1 in turn negatively regulates the association of SNX9 with ta
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br Introduction ACK or Activated Cdc
2025-02-08
Introduction ACK1, or Activated Cdc42-Associated Kinase, located on chromosome 3q, is a ubiquitously expressed non-receptor tyrosine kinase cloned from a human Rac1 protein fragment cDNA library (Manser et al., 1993). It was first identified to bind to activated Cdc42, a small Ras GTPase via its
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pseudouridine A promising target that is involved in the bio
2025-02-08
A promising target that is involved in the biosynthesis of the precursor LTA4 is the 5-LO-activating protein (FLAP), which in vivo is seemingly indispensable for LT formation [8], [9]. FLAP, a member of the MAPEG family (membrane-associated proteins in eicosanoid and glutathione metabolism), is an i
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br Experimental br Results and discussion br Conclusion br A
2025-02-07
Experimental Results and discussion Conclusion Acknowledgments This work is supported by the National Basic Research Program of China (973 Program 2016YFA0201201 and 2013CB932702), a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAP