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br Material and methods br Results and discussion br
2022-01-13
Material and methods Results and discussion Discussion It is well established that the guanosine-rich DNA sequences within telomeric DNA repeats, and in the promoter regions of a number of oncogenes or proto-oncogenes such as c-myc [20,23], VEGF [28,48,49] and Bcl-2 [21,50], can readily ass
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One effective approach to fine tuning the lipophilicity prof
2022-01-13
One effective approach to fine-tuning the lipophilicity profile of FFA1 agonists is to ‘decorate’ the 3-phenylpropahoic caspofungin scaffold with polar heterocyclic moieties. Alternatively, this scaffold could be replaced with heterocyclic isosteres (as in Takeda’s compounds 1,2 and 3 as well as Amg
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br Conclusion br Conflict of interest br Acknowledgements br
2022-01-13
Conclusion Conflict of interest Acknowledgements Introduction The brain contains abundant fatty acids, which serve as constituents of membranes and as an energy source. In addition, fatty acids and their metabolites contribute to signal transduction between neurons or neurons and glial c
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With the nitrogen containing heterocycle components
2022-01-13
With the nitrogen-containing heterocycle components and the acidic components in hand, the final products were synthesized according to the procedure as depicted in . Reaction of – with various β-substituted phenylpropionic YM201636 mg (, and ), followed by deprotection by TFA, smoothly provided the
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br The signal of ferroptosis ROS generated
2022-01-13
The signal of ferroptosis ROS generated by extracellular or intracellular stimuli play a fundamental role in cell and tissue injury in a variety of disease states [47]. Ferroptosis is generally considered as a type of ROS-dependent regulated necrosis [48]. Intracellular iron accumulation and lipi
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Increasing trans epithelial transport efficiency is another
2022-01-13
Increasing trans-epithelial transport efficiency is another area where different strategies are being developed for overcoming transcytosis. Enhancing the affinity for the basal membrane and weakening apical exocytosis through the optimisation of surface hydrophobicity have been demonstrated [79]. S
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Over the years a number
2022-01-13
Over the years, a number of studies have reported results concerning the behavior of the two endothelin receptor subtypes, ETA and ETB, that do not fit the classical model of two G protein-coupled receptors acting independently of one another. For example, in the rat anterior pituitary gland, both E
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Lastly the N position of this
2022-01-13
Lastly, the N-1 position of this privileged pyrimidone was further substituted by a variety of different aromatic, aliphatic or heteroaromatic linkers with carbonyl functionality. In this task, different N-1 substituted pyrimidones 20i–20xiv were generated and check against HIV IN 3′-processing and
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The following are the supplementary data related to this art
2022-01-13
The following are the supplementary data related to this article. Transparency document Introduction Hypoxia is a pathological process that causes abnormal changes in metabolism, function and morphological structure of tissue because of insufficient oxygen supply. It's reported that hypoxia w
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Nevertheless the frequency of CTCs was higher in patients
2022-01-13
Nevertheless, the frequency of CTCs was higher in patients with metastatic breast cancer, which is to be expected because cancer Nivolumab sale from the original clone that caused the metastasis probably had features favoring their spread throughout the body. When we take HER2+ CTC counts ≥ 3 as a “
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Based on our results we propose three possible mechanisms of
2022-01-13
Based on our results, we propose three possible mechanisms of HER2 loss after trastuzumab-based therapy (Fig. 3). The first possibility is a result of the differential effects of treatments on clonal subsets. In breast cancer, such selective pressure has been suggested to preferentially eradicate HE
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The endocytic inhibitors MDC and CPZ and dynamin
2022-01-13
The endocytic inhibitors MDC and CPZ and dynamin GTPase blocker (dynamin mutant) have been shown to significantly decrease the intracellular accumulation of cGMP. Moreover, earlier reports suggested that G-protein-coupled receptor (GPCRs) continue to signal by generating cAMP throughout internalizat
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The experiments reported herein were designed to test
2022-01-13
The experiments reported herein were designed to test whether co-expression of MRP and GSTP1-1 offers a level of protection from certain cytotoxic drugs not achieved by the expression of either protein alone. This was accomplished by stable transfection with expression vectors into MCF7/WT cells, w
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br Materials and methods br Results br Discussion The
2022-01-13
Materials and methods Results Discussion The compound P7C3 has been reported to activate NAMPT (Wang et al., 2014) and augment NAD+ levels, thereby promoting the survival of mature neurons and postnatal neurogenesis throughout the post-ischemic GSK1120212 (Loris et al., 2017). However, it h
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Adenosine triphosphatase ATP is a signaling molecule in acut
2022-01-13
Adenosine triphosphatase (ATP) is a signaling molecule in acute pain and chronic pain(Burnstock, 2009, Burnstock, 2013, Burnstock, 2014, Chizh and Illes, 2001). It is also known that presynaptic A1 receptors are involved in the inhibition of transmitter release (Vizi and Knoll, 1976). Extracellular
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