• br Materials and methods br Results br Discussion Several hi

  2021-12-15

  

  Materials and methods Results Discussion Several histamine H3 receptor antagonists have progressed into clinical development for indications including Alzheimer's disease, schizophrenia, pain and narcolepsy. Each of the compounds studied herein has been extensively characterized in its own

• br Introduction Chronic hepatitis C CHC caused by hepatitis

  2021-12-15

  

  Introduction Chronic hepatitis C (CHC) caused by hepatitis C virus (HCV) infection affects approximately 170 million individuals worldwide [1]. HCV and human immunodeficiency virus (HIV) have similar routes of transmission, including blood-to-blood contact, sharing of injection equipment, and sex

• br GSNOR regulates SA synthesis and

  2021-12-15

  

  GSNOR1 regulates SA synthesis and SA signalling The phenolic metabolite salicylic carnosic acid mg (SA) is a powerful immune activator in plants. Moreover, mutations that disable SA biosynthesis or transgenes that result in its depletion compromise both resistance (R) gene-mediated and basal res

• While a role for YAP TAZ signaling

  2021-12-15

  

  While a role for YAP/TAZ signaling in oligodendrocytes has not been described, these YAP-TEAD Inhibitor 1 are also responsive to mechanical stimuli. OPC proliferation and migration can be altered by plating on substrates of varying stiffness [20], resulting in differentiation in a density-dependent

• The dorsal horn of the spinal cord shows

  2021-12-15

  

  The dorsal horn of the spinal cord shows a high density of Ca2+-permeable AMPA receptors, particularly in the superficial spinal laminae (laminae I and II), where primary afferents carrying nociceptive and thermoreceptive inputs terminate and synapse on spinal second-order neurons (Engelman et al.,

• Both preclinical and clinical studies have identified

  2021-12-15

  

  Both preclinical and clinical studies have identified a distributed set of CNS nuclei that participate in cognitive control of feeding behavior. Preclinical studies that utilize restricted access feeding schedules (RFS) indicate that rodents learn to anticipate delivery of scheduled meals as indicat

• br Ghrelin Ghrelin was purified from

  2021-12-15

  

  Ghrelin Ghrelin was purified from rat stomach about twenty years ago as a 28-amino Cy7 carboxylic acid (non-sulfonated) octanoylated peptide and shown to be the endogenous ligand of the growth hormone (GH) secretagogue receptor (now termed GHSR1a, Howard et al., 1996, Kojima et al., 1999). GHSR1

• Bufalin While the apparent complexity of gap junction

  2021-12-15

  

  While the apparent complexity of gap junction regulation presents challenges, new technologies continue to propel the field forward. Advances in microscopy are increasingly able to capture rapid dynamics at the plasma membrane (e.g., biosensors [67] and lattice light sheet microscopy [100]) and to d

• We found that silymarin induced more improvement of renal fu

  2021-12-15

  

  We found that silymarin induced more improvement of renal functions compared to Rvs. Our results were in agreement with previous studies. The effect of silymarin has been tested in alloxan-induced diabetes mellitus models in rats. Alloxan produces reactive oxygen species which injure renal tissue. S

• br Importance of iron and lipoxygenase in ferroptosis

  2021-12-14

  

  Importance of iron and lipoxygenase in ferroptosis What remains to be somewhat controversial is the role of iron and lipoxygenases (LOX) in the death process, specifically in lipid peroxidation. So far, iron chelators have been repeatedly shown to halt ferroptosis (hence its name) induced by chem

• WT associated protein WTAP a nuclear protein is first identi

  2021-12-14

  

  WT1 associated protein (WTAP), a nuclear protein, is first identified by Little [6] who noticed its specific interaction with WT1. Besides several essential physiological processes, such as mRNA stabilization [7], eye development [8], m6A methylation [9], mRNA alternative splicing [10] and SAR131675

• Given the overexpression of HO in some

  2021-12-14

  

  Given the overexpression of HO-1 in some tumors, such as CML, and its potential involvement in chemoresistance to classical chemotherapeutic agents, compounds 4 and 8f were tested in CML cell lines resistant to IM, a classical TK inhibitor used in CML. Compounds 4 and 8f, in combination with IM, sho

• The effect of microtubule inhibitors

  2021-12-14

  

  The effect of microtubule inhibitors on HBV infection and replication were reported previously. In the study by Dr. Ai-Long Huang's group, microtubule inhibitors promoted HBV replication in Hep2.2.15 and HepG2-HBV1.1, in which HBV DNA is integrated into the chromosomal DNA (Xu et al., 2015). Integra

• Furthermore colistin induced mitochondrial dysfunction in mo

  2021-12-14

  

  Furthermore, colistin induced mitochondrial dysfunction in mouse central nervous system and chicken neurons, axonal degeneration and demyelization of mice sciatic nerves [16,17,19]. Interestingly, mitochondrial dysfunction is a key determinant of neurodegeneration [20,21]. Also, it accumulates amino

• br Acknowledgments br Introduction Manipulating target prote

  2021-12-14

  

  Acknowledgments Introduction Manipulating target protein expression via either induction or suppression of gene expression is a powerful technology that has been widely used in the recent past in the field of neurobiology, both to study the pathophysiological significance of a target gene and

13467 records 347/898 page Previous Next First page 上5页 346347348349350 下5页 Last page