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Two US FDA approved assays are commonly used for VL
2021-12-04
Two US FDA-approved assays are commonly used for VL monitoring: the COBAS AmpliPrep/COBAS® Taqman® HIV-1 version 2.0 (“CAP/CTM HIV-1 v2”; Roche Molecular Systems) [18], and the RealTime HIV-1 assay (“RealTime HIV-1”, Abbott Molecular) [19]. Several studies have shown good correlation between the ass
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br Conclusion br Author contributions br Ethics approval
2021-12-04
Conclusion Author contributions Ethics approval Competing interests Introduction VHL is a well-known tumor suppressor and works as a target recruitment subunit of an E3 ubiquitin ligase complex that recruits hydroxylated hypoxia inducible factor α (HIF-α) for proteasomal degradation u
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In this current study we not only demonstrated the growth
2021-12-04
In this current study, we not only demonstrated the growth-inhibitory effects of the 2nd generation analog SL-1-39 on the HER2+ breast cancer cells, MDA-MB-453 and SKBR3 (Table 1), but we also demonstrated that the decrease in cell number was associated with an interruption of 2 hydroxyglutarate pr
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br Conclusion We conducted single marker
2021-12-04
Conclusion We conducted single-marker association and haplotype association analyses of genetic mutations in porcine SLA-DOB and CD4 genes with T-lymphocyte subsets, cytokines, and Heme Colorimetric Assay Kit in pregnant Landrace sows and obtained the SNPs and insertion that significantly affec
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Epidemiological evidence indicates that neuroinflammation pl
2021-12-03
Epidemiological evidence indicates that neuroinflammation plays a pivotal role in pathogenesis of AD (Heneka et al., 2015, Heneka et al., 2013, Holmes et al., 2009, Liu et al., 2016). For example, prolonged treatment with nonsteroidal anti-inflammatory drugs reduces the risk of developing AD (In et
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In fact changes in mitochondrial dynamics directly affects
2021-12-03
In fact, changes in mitochondrial dynamics directly affects many things including cellular metabolism [127], mitochondrial mass and turnover [128], mitochondrial transport, and calcium buffering [129]. Nigrostriatal DA neurons seem to have a preferential susceptibility to loss of Mfn2 when compared
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In addition at the spinal level results from colocalization
2021-12-03
In addition, at the spinal level, results from colocalization experiments demonstrate that GABA-C receptors are present in the substantia gelatinosa and that they are presynaptically located. Neurons located in the substantia gelatinosa are differentially activated by afferent noxious and non-noxiou
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Fpr appears to be an indispensable component of the signalin
2021-12-03
Fpr2 appears to be an indispensable component of the signaling chain governing dendritic cell trafficking in allergic airway inflammation (Chen et al., 2010). The FPR3 agonist FL2 is chemoattractant for dendritic cells, but its biological role in vivo is yet to be defined. Within the inflammatory s
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br Memories can last a lifetime long
2021-12-03
Memories can last a lifetime, long after the transient events have passed. The fact that information stored in the BKM120 can outlast the environmental trigger implies that enduring cellular changes in the central nervous system underlie memory. Epigenetic modifications of DNA and chromatin struct
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Despite the importance of intratumor phenotypic heterogeneit
2021-12-03
Despite the importance of intratumor phenotypic heterogeneity for tumor progression and therapy resistance (Marusyk et al., 2012, Marusyk and Polyak, 2010), our understanding of regulators of this process and our ability to modulate them are very limited. Recent advances in genomic sequencing and si
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Docetaxel Several named antagonist ligands have figured noti
2021-12-03
Several named antagonist ligands have figured noticeably in preclinical studies, with proved clear ability to release neurotransmitters and having efficacy in preclinical animal models. Consequently, this has encouraged ongoing research on improved agents with potency, selectivity, and better drug-l
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The measured ROcc values and mg kg
2021-12-03
The measured ROcc50 values (4.8 and 42 mg/kg, respectively) were lower than those estimated from the mouse free Azaserine concentrations (0.4 and 9.3 mg/kg for the sigma-1 and histamine H3 receptor, respectively) or rat CSF levels (0.65 and 4.5 mg/kg, respectively). This discrepancy is almost certai
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Linezolid Based on the in vitro findings summarized here we
2021-12-03
Based on the in vitro findings summarized here, we posited that, in the intact brain, release of ROS from iron-laden astrocytes to the local neuropil elicits oxidative damage and degeneration of indigent dopaminergic projections and other vulnerable neuronal elements (Schipper, 2001). Of particular
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Because of its excellent GPR potency good hERG
2021-12-02
Because of its excellent GPR119 potency, good hERG selectivity and favorable rat t, caudatin was scaled-up and further profiled. The synthetic protocols described in , were both suitable for a multi-gram scale synthesis of compound . An off-target screen was performed against an extensive panel o
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Up to now the research about the
2021-12-02
Up to now, the research about the effect of PAs on inhibiting carbohydrase activity in vitro or reducing blood sugar level in vivo was mainly reported in PAs from grape seeds, Lepisanthes alata (Malay cherry) leaves, sorghum, pomegranate, cranberry and persimmon (Banerji and Banerjee, 2016, Barrett
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