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br Materials and Methods br Results br Discussion HSCs have
2021-04-30
Materials and Methods Results Discussion HSCs have been identified as major collagen-producing Birinapant in the injured liver (1), and activation of HSCs has become the central link for liver fibrosis (2). The factors that regulate the biological behavior of HSCs include soluble regulatory
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The present study provides the first
2021-04-30
The present study provides the first evidence that the human uroepithelial p-Cresyl sulfate in vitro respond directly, within 48h, to this carcinogen by promoting extensive vacuolation and DAPK expression. By using the TEM, ICC and Western blotting, we found that the arsenite-induced vacuoles were
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mlkl australia As previously reported azole class antifungal
2021-04-30
As previously reported, azole class antifungal drugs inhibit fungal CYP450 14α-demethylase, as this interrupts the conversion of lanosterol to ergosterol, a component of the fungal cell membrane (Hof, 2006). Furthermore, correlation between fluconazole dose, the extent of hepatic hypertrophy, the le
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Endothelial dysfunction has been associated
2021-04-29
Endothelial dysfunction has been associated with most of the established cardiovascular risk factors, such as hypercholesterolemia, hypertension, smoking, diabetes mellitus, a positive history of premature CAD and elevated AMI-1 homocysteine 4, 26, 27. Endothelial dysfunction is present in the prec
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To study systemic potential of the selected compounds
2021-04-29
To study systemic potential of the selected compounds as EP1 receptor antagonist, they were evaluated with regard to the sulprostane-induced increase of intravesical bladder pressure in rats. Some of the analogs, 13 and 15–17, which were selected on the basis of their in vitro EP1 receptor affinity,
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There may be an interplay of
2021-04-29
There may be an interplay of EP2, EP3, EP4 alone, or in combination, with EP1 for the onset of TCDD-induced neonatal hydronephrosis. EP2 and EP4 have been reported to increase AQP2 phosphorylation and membrane trafficking (Li et al., 2009; Olesen et al., 2011). The EP2 and EP4 mRNA concentrations we
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Many studies reporting on discoveries of DUBs
2021-04-29
Many studies reporting on discoveries of DUBs in the TGFβ and BMP pathways have relied on RNAi strategies to investigate loss-of-function impact. While RNAi strategies are useful tools, there are limitations ranging from limited knockdowns of targets to potential off-target effects. New and better t
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It is well known that nanostructured transition metal oxides
2021-04-29
It is well known that, nanostructured transition metal oxides are the most promising candidates as electrode for pseudocapacitors due to their attractive properties such as environmentally friendly, high theoretical capacitance, low cost and easily abundant [15], [16]. Numerous investigations have b
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It is well known that
2021-04-29
It is well-known that corticotropin-releasing factor (CRF) exerts its biological functions through binding to type-1 (CRF1) and/or type-2 (CRF2) receptors. Several clinical evidences suggest the association of a high level of CRF and the onset of anxiety and depressive disorders.2, 3, 4, 5, 6, 7 Si
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In brief while previous studies
2021-04-28
In brief, while previous studies have evaluated the individual roles of VDR and ER signaling pathways in breast cancer, in the present study we performed an in silico approach for comparative evaluation of these pathways. Considering the complex interaction networks in the context of cancer, such co
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It has previously been shown that human melanocytes are
2021-04-28
It has previously been shown that human melanocytes are responsive to a multiplicity of hormonal triggers [10], particularly to pituitary or ovarian hormones [11]. Studies concerning the effects of blt2 on human melanocytes led to inconsistent data [12], [13]. Im et al. [14] reported that the respo
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Although several genomic technologies including the generati
2021-04-28
Although several genomic technologies, including the generation of ERRγ-specific knockout mice, have revealed that ERRγ plays a pivotal role in cellular bioenergetics [1], its involvement in other metabolic pathways has been appreciated only recently. Therefore, we highlight recent findings on the r
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While agnathans appear to have reduced their Ednr
2021-04-28
While agnathans appear to have reduced their Ednr repertoire to the Ednra gene (that may have been amplified in the Arctic lamprey), gnathostomes in general have been relatively inert to Ednr gene loss. Strikingly, the only Ednr gene that has been lost repeatedly is EdnrB2 (lost in therian mammals,
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br Results br Discussion It has been
2021-04-28
Results Discussion It has been thought that commitment to the plasma cell fate begins while CCG-1423 synthesis are still in the GC (Suan et al., 2017, Victora and Nussenzweig, 2012), but the main obstacle to test this model and, if correct, to clarify how the plasma cell-prone GC cells develo
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A growing number of other post translational modifications
2021-04-28
A growing number of other post-translational modifications are implicated in regulation of the ubiquitin system, including substrate modification by hydroxylation, glycosylation, acetylation, methylation, modification by poly(ADP-ribose) (PAR), and attachment of ubiquitin-like modifiers. The HIF1-α
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