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The human serotonin hydroxytryptamine HT receptor
2021-03-08
The human serotonin (5-hydroxytryptamine; 5-HT) receptor family consists of 14 receptor subtypes to date, which are primarily G protein-coupled receptors (GPCRs) with 5-HT3 being the sole ligand-gated ion channel (Alexander et al., 2017). These receptors are widely distributed in the central and per
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br Materials and methods br Results br
2021-03-08
Materials and methods Results Discussion In this paper, we have demonstrated application of the glmS ribozyme reverse genetic tool for chemogenomic profiling in Plasmodium spp. This tool can provide robust attenuation of expression for different target genes, across different strains varyin
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Moreover the imbalance between pro and anti inflammatory
2021-03-08
Moreover, the imbalance between pro and anti-inflammatory cytokine production is present in various types of diseases. The use of substances able to induce anti-inflammatory cytokines could represent an important advance in the therapeutic treatment of a range of diseases. In this context, medicinal
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In the present study we determined concentration response re
2021-03-08
In the present study, we determined concentration–response relationships for selected synthetic progestogens using in vitro luciferase transactivation assays driven by PR, ARα and ARβ from Murray–Darling rainbowfish () and compared the profiles with those obtained from similar assays based on human
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It seems plausible that this ESC driven
2021-03-08
It seems plausible that this ESC-driven effect relies on a paracrine signaling. Numerous studies showed that the Fgf4 (fibroblast growth factor 4)/MAPK (mitogen-activated protein kinase) pathway is involved in PE differentiation in mouse BIIB021 australia (Chazaud et al., 2006), (Frankenberg et al.
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Several studies have shown that
2021-03-08
Several studies have shown that, independently of body-weight control, the central actions of leptin improve glycemic control in obese diabetic rat and mouse models [62]. For instance, restoration of OB-Rb expression in OB-Rb-deficient mice, and in particular in POMC neurons, was sufficient to norma
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Next we elucidated that the Mtb
2021-03-08
Next, we elucidated that the Mtb enolase binds to host plasminogen with a high affinity. The KD value of 360nM for this interaction suggested an avid binding between the two proteins in vivo. This observation is also in conciliation with the observed KD values for enolase-plasminogen interactions in
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Labetalol HCl br Results and discussion br Conclusion Recent
2021-03-08
Results and discussion Conclusion Recent studies showed that EGFR signaling is involved in inflammatory response in several inflammatory conditions. The normal inflammatory macrophage Labetalol HCl show EGFR-dependent production of inflammatory mediators. Nevertheless, the development of EGFR
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Family and twin studies have estimated the heritability of
2021-03-05
Family and twin studies have estimated the heritability of obesity to be between 40 and 70% [5], [6], [7]. However, all known risk variants can only account for ∼3% of the variance in BMI [8], [9]. Therefore, alternate methods are needed to identify additional risk factors. In recent decades, Drosop
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br Experimental Procedures br Acknowledgments br Introductio
2021-03-05
Experimental Procedures Acknowledgments Introduction Incessant consumption of fossil fuels brings on global energy crisis and serious environmental concerns. Hence, the researchers have paid considerable attention to alternative renewable bioenergy. Microalgae has been considered as potenti
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br CDK Regulators as Coactivators of NF
2021-03-05
CDK Regulators as Coactivators of NF-κB and STAT CDK regulating proteins also have the ability to control the inflammatory response. The p21CIP1 protein binds to and inhibits the activity of cyclin–CDK4/6 and cyclin–CDK1/2 complexes. Consistent with its ability to inhibit CDK activity, deletion o
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br Material and methods br Results Diagrammatic
2021-03-05
Material and methods Results Diagrammatic representations showing the bilateral injection sites in the BNST of all animals used in the present study are presented in Fig. 1. Discussion The present results provide the first evidence that both CRF1 and CRF2 receptors in the BSNT are involved
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br Experimental protocols br Acknowledgements This research
2021-03-05
Experimental protocols Acknowledgements This research was funded by the Croatian Ministry of Science, Education and Sports (Programmes 098-0982915-2948 and 098-0982522-2525), the Austrian Science Fund FWF (DK-MCD W1226, SFB LIPOTOX F30, P22832), and the Croatian-Austrian Intergovernmental S&T
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Co operation or synergy between PKA and Epac
2021-03-05
Co-operation or synergy between PKA and Epac has been recently reported in PCCL3 thyroid cell line in which cAMP is pro-mitogenic, in DTP3 to VSMC [19]. Our study demonstrates for the first time that PKA and Epac also synergise to inhibit cell proliferation in a cell type where cAMP in anti-mitogen
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The host virus coexistence is
2021-03-05
The host-virus coexistence is completely dependent on the balance between a strong immune response inhibiting virus replication and immune evasion and survival of the virus with periodic shedding to enable transmission to new hosts. In the process of ensuring this balance, the virus manipulates 7TM
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