• br Conclusions br Compliance with ethical standards Disclosu

  2020-07-30

  

  Conclusions Compliance with ethical standards Disclosure of potential conflicts of interest: Lei Mao serves as Chief Computing Officer for DrivingForce Therapeutics (DFT); Yongliang Yang is a scientific co-Founder of DFT and Cheng Li is a scientific advisor to DFT. Research involving human pa

• Diabetes mellitus and insulin resistance are disorders that

  2020-07-30

  

  Diabetes mellitus and NVP 231 resistance are disorders that require careful and controlled care considering the use of specific medications, such as the administration of exogenous insulin (type 1 diabetes) or oral hypoglycemic agents (type 2 diabetes and/or insulin resistance) that stimulate insul

• br Experimental Procedures br Acknowledgments br Introductio

  2020-07-29

  

  Experimental Procedures Acknowledgments Introduction Incessant consumption of fossil fuels brings on global energy crisis and serious environmental concerns. Hence, the researchers have paid considerable attention to alternative renewable bioenergy. Microalgae has been considered as potenti

• N,N-Dimethylsphingosine synthesis br Materials and methods b

  2020-07-29

  

  Materials and methods Results To determine the effect of NAT1 deletion on mitochondrial function, OCR and ECAR were measured using a Seahorse XFe96 Flux Analyzer. In MDA-MB-231 cells, basal oxygen consumption, ATP-coupled oxygen consumption and reserve respiratory capacity decreased in the NAT

• br CK signaling during ischemia in brain GM

  2020-07-29

  

  CK2 signaling during ischemia in brain GM In GM, CK2 signaling can be either protective or damaging. For example, in a model of transient forebrain ischemia, the preservation or activation of CK2 activity was proposed to be important for neuronal survival after cerebral ischemia [8]. Specifically

• Several independent investigators have documented disturbanc

  2020-07-28

  

  Several independent investigators have documented disturbances in central NErgic systems and early involvement of the LC in PD (Dickson et al., 2009, German et al., 1992, Marien et al., 2004, Schapira et al., 2006). Experimental lesions of the LC have also been shown to exacerbate PD pathology and b

• DNA PK is a heterotrimeric complex consisting of the catalyt

  2020-07-28

  

  DNA-PK is a heterotrimeric complex consisting of the catalytic subunit DNA-PKcs and a heterodimer of Ku70 and Ku80. DNA-PK binds dsDNA breaks and functions in non-homologous end joining (NHEJ) (Pannunzio et al., 2018) and also in DNA sensing, upregulating type I IFN and cytokines via the STING pathw

• br Experimental br Author contributions br Acknowledgement b

  2020-07-28

  

  Experimental Author contributions Acknowledgement Introduction Microalgae represent an outstanding natural source of biochemically active metabolites [1].These algae-derived products, such as polyunsaturated fatty acids, have significant potential for applications in numerous industrial

• Cytokine evaluation in MPN dates

  2020-07-28

  

  Cytokine evaluation in MPN dates back to 1997. Early studies have evaluated limited subtypes of cytokines because of technology limitations or kit restrictions. Now with the application of multiplex cytokine assays, a panel of cytokines can be measured per sample at the same time and can provide mor

• Although differences in several nociceptive tests have previ

  2020-07-28

  

  Although, differences in several nociceptive tests have previously been described across strains (Mogil et al., 1999), it is the first time that pain sensitivity in response to chemical and thermal stimuli has been evaluated in B6,129CRHtklee mice. Our results showed no differences in pain sensitivi

• br Materials and methods br Results br

  2020-07-28

  

  Materials and methods Results Discussion Cellular senescence was first termed by Hayflick and Moorhead to describe irreversible growth arrest in human diploid cells [45]. It can also be induced by DNA damaging agents, which is attributed to telomere shorting [8]. Numerous examples of senesc

• br Introduction Fibrosis is a major

  2020-07-28

  

  Introduction Fibrosis is a major cause of mortality and morbidity and has been estimated to contribute to at least one third of all deaths worldwide and even 45% of deaths in the developed world [1,2]. Idiopathic pulmonary fibrosis (IPF) is one of the most progressive types of organ fibrosis, wit

• br Acknowledgements br Introduction In

  2020-07-28

  

  Acknowledgements Introduction In Arabidopsis thaliana (L.) Heynh, there are at least four copies of the caseine kinase-like gene Ck1, which is involved in peptide phosphorylation in mammals [1]. These genes are distributed on 2-deoxy-d-glucose receptor 1, 2, 4, and 5. A similar number of copi

• Our study provides proof of principle for

  2020-07-27

  

  Our study provides proof of principle for dimerizing two different E3 ligases as a novel approach to inducing one ligase to degrade the other one. The outcome of ‘ligase versus ligase’ PROTAC-mediated activity might be unpredictable a priori, but could reveal a new mechanism for proximity-mediated h

• To finally ensure that there are no

  2020-07-27

  

  To finally ensure that there are no other alternatives to the YM 90709 receptor of exonuclease activity from Artemis we quantified the endonuclease and exonuclease activities throughout the purification and the results are presented in Table 1. These results clearly demonstrate that following fracti

15093 records 730/1007 page Previous Next First page 上5页 726727728729730 下5页 Last page