Archives
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In the case of high fidelity polymerases
2021-02-26
In the case of high-fidelity polymerases, we propose that water is used to achieve negative selection against nucleotide binding. With specialized DNA polymerases, we propose that nucleobase desolvation plays a different yet important role in allowing these enzymes to replicate damaged DNA. In this
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br Materials and methods br Results
2021-02-26
Materials and methods Results Discussion TP has aroused extensive explorations because of its potent anti-inflammatory, immune-suppressive and antitumor activities. Notwithstanding these, TP has yet to enter Phase II clinical trials owing to its severe toxicity (Zhou et al., 2012). TP could
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In summary these findings show that
2021-02-26
In summary, these findings show that the knockdown of tra2 in the Drosophila fat body results in an increased triglyceride phenotype, which could be explained in part by altered splicing of the gene coding for the lipid breakdown enzyme, CPT1. These findings are consistent with previous studies anal
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br Author contribution br Acknowledgements QNRF grant number
2021-02-26
Author contribution Acknowledgements QNRF grant number NPRP6-065-3-012, Qatar National Research Fund, Doha Qatar for funding this work with grant number NPRP No.: NPRP6-065-3-012. Introduction Preeclampsia (PE) affects 3–5 % of pregnancies worldwide and is one of the leading causes of mate
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One of the therapeutic proteins used in cancer therapy is
2021-02-26
One of the therapeutic proteins used in cancer therapy is glucarpidase, also known as Carboxypeptidase G2, CPG2, which originates from the bacterium Variovorax paradoxus (old name, Pseudomonas sp. strain RS-16). It has no mammalian equivalent (Thompson et al., 1994; Kamlage, 1994) and is a zinc-depe
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Our approach relied on measurement of bulk
2021-02-26
Our approach relied on measurement of bulk solute diffusivity in the three tissue types of interest. Our diffusivity values (Table 3) are on the order of 10−6 cm2/s and are comparable to the PG diffusion coefficient in water at infinite dilution, which is about 10−5 cm2/s at room temperature, as wel
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br Materials and methods br Results and
2021-02-26
Materials and methods Results and discussion Iron (II)/2-oxoglutarate (2-OG)-dependent oxygenases [28], [29] catalyze oxidative reactions of a range of metabolic processes including the hydroxylation of l-proline and l-lysine residues during the post-translational modification of collagen. Mor
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If the effects described here
2021-02-26
If the effects described here are present in catalysis, their empirical confirmation poses many challenges. Cat state correlations are fragile outside an environment especially suited for their preservation. As present day observational techniques whether in vivo or in vitro were not designed bearin
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br Acknowledgments br Introduction br Endothelin receptors S
2021-02-26
Acknowledgments Introduction Endothelin receptors Shortly after the discovery of ET‐1, two types of seven transmembrane G protein‐coupled receptors were cloned called endothelin receptor A (ETA) (Arai et al., 1990) and ETB (Sakurai et al., 1990). The affinity of the ETA receptor for ET-3 is
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Oxidation of N hydroxyguanidine by DbH was studied
2021-02-26
Oxidation of N-hydroxyguanidine 1 by DbH was studied by HPLC and some oxidation products for 1 could be characterized. The compounds generally observed with iron-containing systems are 4-methoxyphenylurea 11 and 4-methoxyphenylcyanamide 12 (Fig. 2). Oxidation of N-(4-chlorophenyl)-N′-hydroxyguanidin
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br Conclusions This report describes the
2021-02-25
Conclusions This report describes the discovery of a new class of host-directed antiviral agents characterized by a 1-aryl-4,6-diamino-1,2-dihydrotriazine scaffold, responsible for a host (human) DHFR inhibition mechanism. Host-targeting antivirals represent an alternative and emerging strategy t
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RG2833 mg In order to derive a
2021-02-25
In order to derive a better understanding of the results from our SAR study, we utilized Glide to model the binding of the SAR compounds with the non-active site pocket of TS-DHFR shown in C. The majority of models position the phenolic moiety of these compounds within the non-active site pocket, wh
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N fowleri enters the host through the nasal cavity
2021-02-25
N. fowleri enters the host through the nasal cavity and travels via the olfactory nerve into the resveratrol where it causes PAM (Visvesvara and Stehr-Green, 1990). The ameba most commonly infects healthy young adults and children and is able to evade the immune system but also elicits extensive da
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It is worth mentioning that in this study we
2021-02-25
It is worth mentioning that, in this study we only observed the responses of CYP450 to the short-term exposure of DSP toxins (12 h). However, the toxic effects of DSP toxins to bivalves appeared to abate with longer exposure (Pinto-Silva et al., 2005; Flórez-Barrós et al., 2011; Prego-Faraldo et al.
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Of note CS associated lung injury is closely
2021-02-25
Of note, CS-associated lung injury is closely linked with augmented influx of macrophages that subsequently intensify the lung injury [34,47] while macrophage depletion alleviates CS-induced pulmonary inflammation via reducing cytokines and chemokine production in BALF [48]. Similar effect has been